田俊生，教授，博士，博士生导师，山西省“三晋英才”科技创新领军人才、山西省“三晋英才”优秀青年人才。兼任中国药理学会网络药理学专业委员会委员、中国药理学会中药与天然产物药理学专业委员会委员、山西省药理学会药物代谢组学专业委员会常务委员兼秘书长、山西省实验动物标准化技术委员会委员，《药学学报》、《中草药》等专业权威期刊编委会委员和青年委员。
主要研究方向：中药药效评价与机制、中医药代谢组学与生物网络调控、中药创新药物研发、中药分析与质量控制。承担国家自然科学基金项目3项、中国博士后科学基金面上项目1项、山西省科技计划项目6项，企事业单位委托横向科研项目30余项，获得省部级科技奖励4项，发表学术论文140篇，其中SCI收录35篇，申请国家发明专利16项，授权8项，专利技术转让3项。指导博士、硕士研究生40名，其中6名硕士生直博，5名获得国家奖学金，3名毕业博士生获得国家自然科学基金青年项目资助。
博士招生专业：本草生物学
硕士招生专业：药学、中药学（专业学位）
联系方式：0351-7011202；jstian@sxu.edu.cn
代表性科研项目:
[1] 主持国家自然科学基金面上项目(82374153)：基于脑内性激素微环境稳态调控的柴归颗粒“调天癸-补髓海”治疗抑郁症作用机制研究，经费48万元. 2024.01-2027.12.（在研）
[2] 主持2025年度山西省“三晋英才”计划科技创新领军人才项目：柴归颗粒治疗产后抑郁症效应与机制研究，经费80万元. 2026.01-20219.01.（在研）
[3] 主持企业委托横向科研项目：基于代谢组学和转录组学的驴胶补血颗粒改善产后体虚效应与机制研究，经费70万元，2023.06-2026.06. （在研）
[4] 主持企业委托横向科研项目：万应胶囊治疗口腔溃疡药效与机制研究，经费36万元，2024.01-2026.12. （在研）
[5] 主持事业单位委托横向科研项目：基于LC-MS代谢组学的香附炮制品治疗气滞血瘀型抑郁症的作用机制研究，经费24万元，2025.01-2026.12.（在研）
[6] 主持国家自然科学基金青年项目(81102833)：基于cAMP-PKA-CREB-BDNF信号转导通路的逍遥散有效部位抗抑郁作用机制，20万元. 2012.01~2014.12.（已结题）
[7] 主持国家自然科学基金综合管理项目(81441096)：基于代谢网络调控的逍遥散抗抑郁有效部位作用机制研究，10万元，2015.01~2015.12. (已结题)
[8] 主持中国博士后科学基金面上项目（2016M602414）：基于系统药理学的驴胶补血颗粒升白作用机制研究，5万元，2016.11~2018.12. (已结题)
[9] 主持山西省科技厅重点研发计划（社会发展）一般项目(201903D321210)：基于肠道菌群-代谢物组互作网络阐释抗抑郁中药新药柴归颗粒的作用机理，10万元2019/07-2021/12（已结题）
[10] 主持山西省基础研究计划面上项目（202103021224026）：柴归颗粒调控亮氨酸分解代谢改善社交挫败抑郁行为分子机制，经费8万元，2022.01-2024.12.（已结题）
[11] 主持山西省自然科学基金面上项目(201701D121137)：逍遥散抗抑郁系统生物网络调控机制研究，经费3万元，2017.07-2019.12.（已结题）
[12] 主持山西省科技攻关计划项目（201603D321077）：基于同位素示踪与2D-LC-MS技术的抑郁症诊断生物标志物研究，经费5万元，2016.01-2018.12. (已结题)
[13] 主持山西科技计划青年项目(2012021031-2)：基于cAMP-PKA-CREB-BDNF信号转导通路的复方柴归抗郁有效组分作用机制，经费5万元，2012.01~2014.12.（已结题）
[14] 参与“重大新药创制”科技重大专项(2017ZX09301047)：抗抑郁中药新药柴归颗粒临床前研究，经费：162.83万元，2017.1~2020.12（第二参与人）（已结题）
[15] 参与国家国际科技合作计划项目(2011DFA32630)：从逍遥散古方中研发抗抑郁现代中药，经费：280万元，2012.1~2015.1（第二参与人）（已结题）
[16] 参与“重大新药创制”科技重大专项(2012ZX09103201-305)：复方柴归抗郁组分新药候选药物研究，经费：130万元，2012.1~2015.12（第二参与人）（已结题）
[17] 参与国家自然科学基金面上项目(81173366)：逍遥散抗抑郁疗效生物标志物分析及机理研究，经费：62万元，2012.1-2015.12；（第三参与人）（已结题）
[18] 参与国家自然科学基金面上项目(31070295)：基于代谢组学的柴胡种质资源功效评价研究，经费：32万元，2011.1~2013.12（第三参与人）（已结题）
[19] 参与山西省重点研发计划项目(201603D3113013)：治疗抑郁症中药新药柴归颗粒临床前研究，经费：70万元，2016.12~2019.12；（第二参与人）（在研）
代表性学术论文（通讯作者）：
[1] Zeng-ning Wu, Hui-ling Zhao, Qi Wang, Jian-li Chen, Yan Ren*, Xue-mei Qin*, Jun-sheng Tian*. Analysis of a new anti-depression mechanism of Chaigui granules based on multi-omics integration: In-depth mining of intestinal microbiota-metabolite interaction network. Journal of Affective Disorder. 2026, 393:120319. （SCI 2区TOP）
[2] Yun-hao Zhao, Qi Wang, Zeng-ning Wu, Yu-zhi Zhou, Xiao-xia Gao, Wen-xia Gong, Xue-mei Qin*, Yan Ren*, Jun-sheng Tian*. Modified Xiaoyaosan rescues depression-like behavior via remodeling gut microbiota and leucine metabolism. Phytomedicine. 2025, 147:157241.（SCI 1区TOP）
[3] Yun-hao Zhao, Ting Ling-hu, Qi Wang, Xue-mei Qin*, Jun-sheng Tian*. Metabolic flux analysis uncovers substrate-specific reprogramming and ATP deficit in CORT-induced depressive-like astrocytes. Journal of Proteome Research. 2025, 24(11):5894-5903. （SCI 2区）
[4] Yun-hao Zhao, Qi Wang, Jian-li Chen, Xing-kang Wu, Hui-chun Zhao, Hui-wu Liu, Xue-mei Qin, Jun-sheng Tian*. Metabolomic analysis reveals chemical changes in Atractylodes macrocephala before and after processing with different methods. Journal of Liquid Chromatography & Related Technologies, 2025. 2604742.（SCI 4区）
[5] Huan Xiang, Xin-jie Wu, Chen Yang, Yu Li, Yihao Meng, Xin Zhang, Jun-sheng Tian*. Component identification and integrated quality evaluation of Zhuyeqing Liquor by UHPLC–Q-TOF–MS and UHPLC–PDA. Separation Science Plus, 2026, 9: e70207.
[6] Qi Wang, Yun-hao Zhao, Xue-mei Qin*, Jun-sheng Tian*. Deciphering relationship between depression and microbial molecules based on multi-omics: A case study of Chaigui Granules. Chinese Herbal Medicine. 2024, 16(4): 612-621.（SCI 2区）
[7] Qi Wang, Zhen-ning WU, Huan Xiang, Yu-zhi Zhou, Xue-mei Qin, Jun-sheng Tian*. Revealing the role of leucine in improving the social avoidance behavior of depression through a combination of untargeted and targeted metabolomics[J]. Food & Function, 2023, 14, 6379.（SCI 1区TOP）
[8] Gao Yao, Zhao Hui-liang, Xu Teng, Jun-sheng Tian,*, Qin Xue-mei*. Identification of crucial genes and diagnostic value analysis in major depressive disorder using bioinformatics analysis. Combinatorial Chemistry & High Throughput Screening. 2022; 25(1):13-20.（SCI 4区）
[9] Ting Ling-hu, Shao-bo Liu, Yao Gao, Yu-mei Han, Jun-sheng Tian,* and Xue-mei Qin*. Stable Isotope-Resolved Metabolomics Reveals the Abnormal Brain Glucose Catabolism in Depression Based on Chronic Unpredictable Mild Stress Rats. Journal of Proteome Research. 2021, 20, 3549-3558.（SCI 2区）
[10] Ting Linghu, Caichun Liu, Qi Wang, Junsheng Tian , Xuemei Qin (2021) Discovery of biomarkers for depressed patients and evaluation of Xiaoyaosan efficacy based on liquid chromatography-mass spectrometry, Journal of Liquid Chromatography & Related Technologies, 44:11-12, 538-549. （SCI 4区）
[11] Gao Yao, Li Xiao, Zhao Hui-liang, Ling-Hu Ting, Zhou Yu-zhi, Tian Jun-sheng*, Qin Xue-mei*. Comprehensive Analysis Strategy of Nervous-Endocrine-Immune-Related Metabolites to Evaluate Arachidonic Acid as a Novel Diagnostic Biomarker in Depression. Journal of Proteome Research. 2021, 20, 2477-2486. （SCI 2区）
[12] Xiao-li Shen, Huan Liu, Huan Xiang, Xue-mei Qin, Guan-hua Du, Jun-sheng Tian*. Combining biochemical with 1H NMR-based metabolomics approach unravels the antidiabetic activity of genipin and its possible mechanism. Journal of Pharmaceutical and Biomedical Analysis, 2016, 129: 80-89.（SCI 3区）
[13] Cai-chun Liu, Guang-ming Feng, Xiao-xia Gao, Yu-zhi Zhou, Wen-jing Hou, Xue-mei Qin, Guan-hua Du*, Jun-sheng Tian*. Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional Chinese medicine formula Xiaoyaosan: A 1H NMR-based metabolomics approach. Journal of Affective Disorders, 2015, 185: 156-163.（SCI 2区）
[14] Jian-li Chen, Bi-yun Shi, Huan Xiang, Wen-jing Hou, Xue-mei Qin, Jun-sheng Tian*, Guan-hua Du*. 1H NMR-based metabolic profiling of liver in chronic unpredictable mild stress rats with genipin treatment. Journal of Pharmaceutical and Biomedical Analysis, 2015, 115: 150-158.（SCI 3区）
[15] Guo-jiang Peng, Jun-sheng Tian*, Xiao-xia Gao, Yu-zhi Zhou, Xue-mei Qin*. Research on the Pathological Mechanism and Drug Treatment Mechanism of Depression. Current Neuropharmacology, 2015, 13, 514-523.（SCI 3区）
[16] Xiao-fen Zheng, Jun-Sheng Tian*, Peng Liu, Jie Xing, Xue-mei Qin. Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H-NMR-based metabonomics. Journal of Ethnopharmacology, 2014, 151(2):912-920. （SCI 3区）
[17] Bi-yun Shi, Jun-sheng Tian*, Huan Xiang, Xiao-qing Guo, Li-zeng Zhang, Guan-hua Du, Xue-mei Qin. A 1H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats. Behavioural Brain Research, 2013(241):86-91.（SCI 3区）
代表性学术论文（第一作者）：
[1] Jun-sheng Tian, Xian-xian, Wen-ze Wu, Yun-hao Zhao, Ting Ling-hu, Xue-mei Qin*. Stable isotope tracer technique and network pharmacology to reveal antidepressant targets and active components of xiaoyaosan. Chemistry Biodiversity. 2024, 21(4): e202301736. （SCI 3区）
[2] Jun-sheng Tian, Yun-hao Zhao, Ting Ling-hu, Wen-ze Wu, Xian-xian Wang, Cui Ji, Wei-di Zhao, Yu-mei Han, Xue-mei Qin*. A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats. Journal of Affective Disorders, 2023,331,121-129. （SCI 2区TOP）
[3] Jun-sheng Tian, Zhen-ning Wu, Dan Wu, Chen Yang, Yao Gao, Dong-lan Yan, Xue-mei Qin. Combining network pharmacology and experimental verification to reveal the mechanism of Chaigui granules in the treatment of depression through PI3K/Akt/mTOR signaling pathways. Metabolic Brain Disease, 2023,38(8):2849-2864.（SCI 3区）
[4] Jun-Sheng Tian*, Peng-Fei Qin, Teng Xu, Yao Gao, Yu-Zhi Zhou, Xiao-Xia Gao, Xue-Mei Qin*, Yan Ren*. Chaigui granule exerts anti-depressant effects by regulating the synthesis of Estradiol and the downstream of CYP19A1-E2-ERKs signaling pathway in CUMS-induced depressed rats. Frontiers in Pharmacology,2022,13:1005438. （SCI 2区）
[5] Jun-sheng Tian*, Wen-ze Wu, Shao-bo Liu, Ting Ling-hu, Yun-hao Zhao, Yao Gao, Xue-mei Qin. Stable Isotope-Resolved Metabolomics Studies on Corticosteroid-Induced PC12 Cells: A Strategy for Evaluating Glucose Catabolism in an in Vitro Model of Depression. Journal of Proteome Research,2022,21 (3):788-797. （SCI 2区）
[6] Jun-Sheng Tian*, Hui-Liang Zhao, Yao Gao, Qi Wang, Huan Xiang, Xiang-Ping Xu*, Sheng Huang*, Dong-Lan Yan, Xue-Mei Qin. Branched-chain amino acids catabolism pathway regulation plays a critical role in the improvement of leukopenia induced by cyclophosphamide in 4T1 tumor-bearing mice treated with Lvjiaobuxue granule. Frontier Pharmacology, 2021,25, 12: 657047. （SCI 2区）
[7] Jun-sheng Tian*, Yan Meng, Yan-fei Wu, Lei Zhao, Huan Xiang, Jin-ping Jia, Xue-mei Qin*. A novel insight into the underlying mechanism of Baihe Dihuang Tangimproving the state of psychological suboptimal health subjects obtained from plasma metabolic profiles and network analysis. Journal of Pharmaceutical and Biomedical Analysis, 2019, 169, 99-110. （SCI 3区）
[8] Jun-sheng Tian*, Shao-bo Liu, Xiao-yan He, Huan Xiang, Jian-li chen, Yao Gao, Yu-zhi Zhou, Qin Xue-mei. Metabolomics studies on corticosterone-induced PC12 cells: A strategy for evaluating an in vitro depression model and revealing the metabolic regulation mechanism. Neurotoxicology and Teratology, 2018, 69, 27–38. （SCI 3区）
[9] Tian Jun-shen*, Zhao Lei, Shen Xiao-li, Liu Huan, Qin Xue-mei. 1H NMR-based metabolomics approach to investigating the renal protective effects of Genipin in diabetic rats. Chinese Journal of Natural Medicines, 2017, 16(4), 0261-0270.（SCI 4区）
[10] Jun-sheng Tian*, Xiao Zhang, Huan Liu, Huan Xiang, Jie Xing, Li-zeng Zhang and Xue-mei Qin*. The hematinic effect of Colla corii asini (Ejiao) using 1H-NMR metabolomics coupled with correlation analysis in APH-induced anemic rats. RSC Advance, 2017, 7, 8952-8962. （SCI 2区）
[11] Jun-sheng Tian, Xiao-tao Xia, Yan-fei Wu, Lei Zhao, Huan Xiang, Guan-hua Du, Xiang Zhang, Xue-mei Qin*. Discovery, screening and evaluation of a plasma biomarker panel for subjects with psychological suboptimal health state using 1H-NMR-based metabolomics profiles. Scientific Reports, 2016, 6:33820.（SCI 2区）
[12] Jun-sheng Tian*, Guo-jiang Peng, Yan-fei Wu, Jian-jun Zhou, Xiao-xia Gao, Yu-zhi Zhou, Xue-mei Qin*, Guan-hua Du. A GC-MS urinary quantitative metabolomics analysis in depressed patients treated with TCM formula of Xiaoyaosan. Journal of Chromatography B, 2016, 1026:227-239（SCI 3区）
[13] Jun-sheng Tian, Cai-chun Liu, Huan Xiang, Xiao-fen Zheng, Guo-jiang Peng, Xiang Zhang, Guan-hua Du* and Xue-mei Qin*. Investigation on the antidepressant effect of sea buckthorn seed oil through the GC-MS-based metabolomics approach coupled with multivariate analysis. Food & Function, 2015, 6.3585-3592.（SCI 1区）
[14] Jun-sheng Tian, Guo-jiang Peng, Xiao-xia Gao, Yu-zhi Zhou, Jie Xing, Xue-mei Qin*, Guan-hua Du*. Dynamic analysis of the endogenous metabolites in depressed patients treated with TCM formula Xiaoyaosan using urinary 1H NMR-based metabolomics. Journal of Ethnopharmacology, 2014(158):1-10.（SCI 3区）
[15] Jun-Sheng Tian, Bi-yun Shi, Huan Xiang, Shan Gao, Xue-mei Qin*, Guan-hua Du. 1H-NMR-Based Metabonomic Studies on the Anti-Depressant Effect of Genipin in the Chronic Unpredictable Mild Stress Rat Model. Plos One, 2013, 8(9):e75721.（SCI 2区）
[16] Jun-Sheng Tian, Yuan-lu Cui*, Li-ming Hu, Shan Gao. Antidepressant-like effect of genipin in mice. Neuroscience Letters, 2010(479):236-239.（SCI 4区）
获得科技奖励：
[1] 谢安，夏新华，田俊生，徐向平，刘血松，颜冬兰，欧金秀，谷陟欣. 驴胶补血颗粒系列关键技术的创建及产业化应用. 湖南省科技进步二等奖，2021-7-20，20204276-J2-303-D04.
[2] 李震宇，秦雪梅，田俊生，张福生，李爱平. 基于代谢组学技术的中药质量评价研究与应用. 山西省科技进步二等奖，2021-03-15，2019-J-2-045.
[3] 秦雪梅，杜冠华，田俊生，武嫣斐，高晓霞，周玉枝，李震宇，张丽增. 逍遥散抗抑郁作用及其代谢组学机制研究与应用. 山西省科技进步二等奖，2020-01-15，2018-J-2-051.
[4] 周玉枝,宫文霞,田俊生,秦雪梅,高晓霞,张丽增. 基于系统性思想的经典古方逍遥散解郁药效物质及其核心药对配伍机制研究. 山西省自然科学二等奖，2024-03-22，2023-Z-2-012
授权发明专利：
[1] 田俊生,颜磊,秦雪梅,向欢,张丽增. 一种快速识别驴胶补血颗粒中化学成分的方法[P]. 山西省：ZL 201910408868.8, 2019-08-20.（已转让）
[2] 田俊生,王琦,颜磊,向欢,秦雪梅. 一种快速识别百合地黄汤中化学成分的方法[P]. 山西省：ZL 201910709476.5, 2021-05-14.
[3] 田俊生. 改善心理亚健康状态的药物组合物及其制备方法和应用[P]. 山西省
ZL 201510180643.3, 2018-04-03
[4] 田俊生, 张丽增, 秦雪梅. 沙棘籽油在制备预防和/或治疗抑郁症药物中的应用[P]. 山西省，ZL 201210146971.8，2013-10-30（已转让）
[5] 高耀, 秦雪梅, 田俊生, 令狐婷. 一种生物标志物代谢通路及分析方法与应用[P]. 山西省：ZL 201910567765.6, 2021-07-27.
[6] 令狐婷，秦雪梅，田俊生，高耀，张丽增.一种基于稳定同位素示踪代谢组学鉴定抑郁症能量代谢异常通路的方法[P].山西省，ZL 202010535066.6，2022-03-18.
[7] 向欢，颜磊，王晶晶，陈安平，田俊生.一种具有升高白细胞作用的中药活性成分组合物[P].山西省，CN 201910665998.X，2022-01-28.（已转让）
[8] 杨波，杨晨，王庆亮，孟亦浩，张鑫，田俊生，秦雪梅。 一种基于UPLC-Q-TOF-MS技术的竹叶青酒化学成分快速识别的方法[P].山西省，CN202210421208.5，2024-01-19.